HyperPKPD Tutor: Interactive Population PK and Exposure–Response

Free interactive tutor for population PK (1–3 compartment, TMDD) and exposure–response (linear, log-linear, Emax, Hill, hockey-stick) with equations and quizzes.

• Population PK simulator: 1-, 2- and 3-compartment oral and IV bolus models, plus target-mediated drug disposition (TMDD) with 1 or 2 compartments.
• Compare three populations side by side: edit clearance, volume, absorption, dose, interval and covariates (weight, creatinine clearance) and see the effect on concentration–time curves.
• Steady-state exposure metrics: Cmax, Cmin, Cavg, AUC over the dosing interval, accumulation ratio and time within the therapeutic window.
• Exposure–response models: linear, log-linear, Emax, sigmoidal Emax (Hill) and hockey-stick (threshold), with the concentration needed for a target effect.
• Worked equations, parameter interpretation and assumptions for every model.
• Concept quizzes with explanations for population PK and for each exposure–response model.
• Runs entirely in your browser; your settings are saved locally. Installable as an app and usable offline.